Allakos Says Phase 3 Study Of Lirentelimab In EoD Missed Symptomatic Co-primary Goal

RTTNews | 965 days ago
Stocktwits
Allakos Says Phase 3 Study Of Lirentelimab In EoD Missed Symptomatic Co-primary Goal

(RTTNews) - Biotechnology company Allakos Inc. (ALLK) on Friday reported data from EoDyssey, a 24-week, Phase 3, randomized, double-blind, placebo-controlled study of lirentelimab in patients with biopsy confirmed eosinophilic duodenitis (EoD).

The trial met its histologic co-primary endpoint, but it did not achieve statistical significance on the patient reported symptomatic co-primary endpoint, in both the intent to treat (ITT) population and in a prespecified subpopulation.

The prespecified subpopulation was based on a post hoc analysis of the Company's phase 3 ENIGMA2 study and excluded certain patients with conditions that could confound the patient reported symptomatic endpoint. Although positive numerical trends in the symptomatic endpoint were observed in this prespecified subpopulation, the results were not statistically significant.

Currently Allakos is not planning to conduct additional studies in eosinophilic gastrointestinal diseases, but may do so in the future. Allakos is focusing development efforts for lirentelimab in atopic dermatitis and chronic spontaneous urticaria and on AK006.

Tags: ALLK
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Tesla Chair Denies Report Of CEO Search To Replace Elon Musk

Tesla Chair Denies Report Of CEO Search To Replace Elon Musk

Tesla Inc. chair Robyn Denholm has denied a Wall Street Journal report that its board was searching for a replacement for Chief Executive Officer Elon Musk. On the social media platform X, she called the report as "absolutely false." Shares of Tesla had fallen around 3 percent on Wednesday's trading following the news. However, with the denial of the report, the stock is currently gaining.
RTTNews | 39 minutes ago
UK Mortgage Approvals Lowest In 8 Months

UK Mortgage Approvals Lowest In 8 Months

UK mortgage approvals decreased to the lowest level in eight months in March despite home buyers rushing to complete the transactions ahead of the rise in stamp duty, official data revealed on Thursday. Mortgage approvals decreased 800 to 64,309 in March, the Bank of England said. Approvals for house purchases, an indicator of future borrowing, decreased for the third straight month.
RTTNews | 1h 32min ago
Yen Slides As Bank Of Japan Retains Rate As Expected

Yen Slides As Bank Of Japan Retains Rate As Expected

The Japanese yen weakened against other major currencies in the Asian session on Thursday, after the Bank of Japan left its interest rate unchanged for the second consecutive meeting and downgraded its growth projections citing trade tariff threats.
RTTNews | 4h 31min ago
Commodity Currencies Rise Amid Risk-on Mood

Commodity Currencies Rise Amid Risk-on Mood

The commodity currencies such as Australia, the New Zealand and the Canadian dollars strengthened against their major currencies in the Asian session on Thursday amid increased risk-on mood, as traders booked some profits after the recent upside in markets and a report showing the U.S. economy unexpectedly shrank in the first three months of 2025 generated some optimism about the outlook for interest rates.
RTTNews | 4h 46min ago
Yen Slides Against Majors

Yen Slides Against Majors

The Japanese yen strengthened against other major currencies in the Asian session on Thursday.
RTTNews | 5h 56min ago
Bank Of Japan Retains Rate As Expected; Cuts Growth Outlook Amid Tariff Uncertainty

Bank Of Japan Retains Rate As Expected; Cuts Growth Outlook Amid Tariff Uncertainty

The Bank of Japan left its interest rate unchanged for the second consecutive meeting on Thursday, and downgraded its growth projections citing trade tariff threats. The policy board decided, by a unanimous vote, to hold the uncollateralized overnight call rate to remain at around 0.50 percent. This was the highest level since the global financial crisis in 2008.
RTTNews | 5h 57min ago
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