Reklāma
EFFECTOR Reports Results Of Phase2 KICKSTART Trial Of Tomivosertib-Pembrolizumab In NSCLC
(RTTNews) - eFFECTOR Therapeutics, Inc. (EFTR) announced Thursday topline results from the primary analysis of the randomized Phase 2 KICKSTART trial which tested tomivosertib or placebo, each combined with pembrolizumab, as frontline treatment for patients with non-small cell lung cancer (NSCLC) with PD-L1 =50%.
Based on 36 events, the hazard ratio for progression free survival (PFS), the primary endpoint of the study, using a stratified Cox proportional hazards model was 0.62 in favor of tomivosertib.
The two-sided p value for PFS, based on a stratified log rank test, was 0.21, which did not meet the pre-specified threshold of p=0.2. The median PFS was 13.0 weeks in the tomivosertib plus pembrolizumab arm and 11.7 weeks in the placebo plus pembrolizumab arm, respectively.
Overall survival results remain immature, however no trend favoring tomivosertib was observed. There were 67% Grade 3 or higher treatment emergent adverse events in the tomivosertib plus pembrolizumab arm versus 37% in the placebo plus pembrolizumab arm.
EFFECTOR Says First Patient Dosed In Second Cohort Of Phase 1b Trial Of Zotatifin For COVID-19
Sensex, Nifty End Choppy Session Marginally Lower
DAX Extending Gains To 7th Session
European Shares Rise On Trade Deal Hopes
Asian Shares Mixed As China's Factory Activity Contracts
German Economy Recovers On Spending, Investment
Canadian Dollar Climbs Against Most Majors
