Mirati, Aadi To Evaluate Adagrasib, Nab-sirolimus Combination To Treat NSCLC, Other Solid Tumors

RTTNews | 930 days ago
Stocktwits
Mirati, Aadi To Evaluate Adagrasib, Nab-sirolimus Combination To Treat NSCLC, Other Solid Tumors

(RTTNews) - Oncology company Mirati Therapeutics, Inc. (MRTX) and biopharmaceutical company Aadi Bioscience, Inc. (AADI) announced Wednesday a clinical collaboration to evaluate the combination of adagrasib, a KRASG12C selective inhibitor, and nab-sirolimus, a small molecule mTOR inhibitor complexed with human albumin in KRAS G12C mutant non-small cell lung cancer (NSCLC) and other solid tumors.

The primary objective of this multi-center, single-arm, open-label Phase 1/2 trial is to determine the optimal dose and recommended Phase 2 dose for the combination of adagrasib and nab-sirolimus in patients with KRASG12C - mutant solid tumors.

In addition, the study will investigate the safety, tolerability and efficacy of adagrasib and nab-sirolimus in combination in patients both with and without prior exposure to a KRASG12C inhibitor.

The trial will build on preclinical data showing enhanced anti-tumor efficacy with the combination of adagrasib and nab-sirolimus relative to either agent alone.

Under the terms of the collaboration agreement, Mirati will be responsible for sponsoring and operating the Phase 1/2 study, and jointly with Aadi, will oversee and share the cost of the study.

For More Such Health News, visit rttnews.com

Tags: AADI MRTX
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Taiwan Stock Market May Add To Its Winnings On Wednesday

Taiwan Stock Market May Add To Its Winnings On Wednesday

The Taiwan stock market has finished higher in three straight trading days, gathering more than 750 points or 3.7 percent in that span. The Taiwan Stock Exchange now sits just above the 20,230-point plateau and it's tipped to open in the green again on Wednesday.
RTTNews | 27 minutes ago
Japan Retail Sales Climb 3.1% On Year In March

Japan Retail Sales Climb 3.1% On Year In March

The value of retail sales in Japan was up 3.1 percent on year in March, the Ministry of Economy, Trade and Industry said on Wednesday - coming in at 14.063 trillion yen.
RTTNews | 42 minutes ago
Japan Industrial Output Sinks 1.1% In March

Japan Industrial Output Sinks 1.1% In March

Industrial production in Japan was down a seasonally adjusted 1.1 percent on month in March, the Ministry of Economy, Trade and Industry said on Wednesday.
RTTNews | 47 minutes ago
Singapore Bourse Expected To Halt Losing Streak On Wednesday

Singapore Bourse Expected To Halt Losing Streak On Wednesday

The Singapore stock market has moved lower in four straight sessions, slumping more than 25 points or 0.7 percent in that span. The Straits Times Index now sits just above the 3,805-point plateau although it's due for support on Wednesday.
RTTNews | 57 minutes ago
Rebound Anticipated For Malaysia Stock Market

Rebound Anticipated For Malaysia Stock Market

The Malaysia stock market on Tuesday snapped the four-day winning streak in which it had gathered more than 35 points or 2.2 percent. The Kuala Lumpur Composite Index now sits just above the 1,515-point plateau although it figures to bounce higher again on Wednesday.
RTTNews | 1h 27min ago
Japan Market May Crack Resistance At 36,000 Points

Japan Market May Crack Resistance At 36,000 Points

Ahead of Tuesday's holiday for Showa Day, the Japanese stock market had finished higher in four straight sessions, collecting almost 1,650 points or 4.6 percent along the way. The Nikkei 225 now sits just beneath the 35,840-point plateau and it's got a solid lead for Wednesday's trade.
RTTNews | 1h 42min ago
Higher Open Predicted For South Korea Shares

Higher Open Predicted For South Korea Shares

The South Korea stock market has moved higher in three straight sessions, collecting more than 40 points or 1.7 percent in that span. The KOSPI now sits just above the 2,565-point plateau and it's expected to open to the upside again on Wednesday.
RTTNews | 1h 57min ago
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